65277-42-1
- Product Name：Ketoconazole
- Molecular Formula：C26H28Cl2H4O4
- Purity：99%
- Molecular Weight：531.439
Product Details;
CasNo： 65277-42-1
Molecular Formula： C26H28Cl2H4O4
Appearance： White powder
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What is the Ketoconazole ?
Ketoconazole is White powder, while it's Molecular Formula is C26H28Cl2H4O4. Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor
What is the CAS number for Ketoconazole ?
The CAS number of Ketoconazole is 65277-42-1.
More information of Ketoconazole 65277-42-1 are:
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Synonyms |
Ketoconazole [USAN:BAN:INN:JAN];Ketoconazol [INN-Spanish];1-acetyl-4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine;Ketoconazole (JAN/USP);Nizoral (TN);KW-1414;(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine;Nizoral;cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-diox olan- 4-yl)methoxy)phenyl)-piperazine;Prestwick_744;Fungarest;1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;Fungoral;Ketoconazol;Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-;Ketoderm;cis-1-Acetyl-4-[4-[2-(2,4-dichlorophenyl)-2-(1H-cmidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl]pipenazine; |
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CAS Number |
65277-42-1 |
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Molecular Formula |
C26H28Cl2H4O4 |
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Molecular Weight |
531.439 |
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Density |
1.38 cm3 |
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Melting Point |
146 °C |
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Boiling Point |
753.4 °C at 760 mmHg |
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Flash Point |
409.4 °C |
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HS CODE |
2941.90 |
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PSA |
69.06000 |
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LogP |
4.20870 |
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Pka |
pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain) |
What is Ketoconazole (65277-42-1) used for?
Ketoconazole (Nizoral), an orally effective broadspectrum antifungal agent, blocks hydroxylating enzyme systems by interacting with cytochrome P450 at the heme iron site to inhibit steroid and/or androgen synthesis in adrenals, gonads, liver, and kidney. The most sensitive site of action appears to be the C17-20 lyase reaction involved in the formation of sex steroids. This explains the greater suppressibility of testosterone production than with cortisol. Cholesterol side-chain cleavage and 11β/18-hydroxylase are secondary sites of inhibition.
InChI:InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23?,26-/m0/s1
Articles related to Ketoconazole:
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Article |
Source |
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Preparation method of ketoconazole |
- , (2018/04/03) |
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A chiral enantioseparation generic strategy for anti-Alzheimer and antifungal drugs by short end injection capillary electrophoresis using an experimental design approach |
Abdel-Megied, Ahmed M.,Hanafi, Rasha S.,Aboul-Enein, Hassan Y. , p. 165 - 176 (2017/11/27) |
How to get the best price on Ketoconazole?
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