3458-28-4

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Mannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.

Source

D-mannose is a sugar that can be found in some fruits and vegetables, such as oranges, apples, peaches, broccoli and green beans. It has been used in the past to treat UTIs in animals. Now, there is some interest into whether it could also treat and prevent UTI in humans.D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It’s metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won’t interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.

Purification Methods

Crystallise -D(+)-mannose repeatedly from EtOH, aqueous 80% EtOH, AcOH or MeOH/propan-2-ol and then dry it in vacuo over P2O5 at 60o. [For 1H NMR and equilibr

General Description

D-Mannose is a monosaccharide sugar that serves as a key chiral starting material in synthetic chemistry, particularly for the preparation of optically active intermediates in the synthesis of complex molecules like maytansinoids, which have potential anti-cancer applications. It is also involved in studies exploring glycosylation reactions, where its derivatives help elucidate the reactivity and conformational preferences of the mannosyl cation, crucial for pharmaceutical development. Additionally, D-Mannose participates in heterocyclization reactions under varying conditions, contributing to the understanding of carbohydrate-derived processes and the formation of thiadiazoline derivatives. Its isomerization and derivatization further highlight its versatility in organic synthesis, though some derived products may lack significant pharmacological activity.

Application

D-mannose is a simple sugar structurally related to glucose. It is absorbed slowly from the gastrointestinal tract, and then a large proportion of it is excreted into the urine.D-(+)-Mannose has been used:as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersaas a medium component for the selection of P898012 sorgum seeds transfected with Agrobacteriumin segmented filamentous bacterium (SFB) medium supplement for culturing human cell linesMannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.

Definition

ChEBI: D-Mannopyranose having alpha-configuration at the anomeric centre.