79794-75-5
- Product Name：Loratadine
- Molecular Formula：C22H23ClN2O2
- Purity：99%
- Molecular Weight：382.89
Product Details;
CasNo： 79794-75-5
Molecular Formula： C22H23ClN2O2
Appearance： white crystalline solid
Quality products make an important contribution to long-term revenue and profitability. China cas 79794-75-5 factory wholesale Loratadine at affordable price
1.What is the Loratadine ?
Loratadine (Claritin) is a long-acting, potent peripheral H1 blocker with minimal sedative effects. It does not appear to have the same adverse cardiac effects as the other nonsedating H1 antihistamines. It is indicated for allergic rhinitis and chronic urticaria.
Loratadine, is used as a peripheral histamine H1 receptor agonist. It is also used as an orally active antiallergic agent. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.
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216870-24-5
diethyl N-ethoxycarbonylpiperidine-4-phosphonate
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79794-75-5
loratadine
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
N,N-dimethyl acetamide; isopropyl alcohol;
at 20 - 140 ℃;
for 2h;
under 760.051 Torr;
|
82% |
-
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541-41-3
chloroformic acid ethyl ester
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38092-89-6
N-methyldesloratadine
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79794-75-5
loratadine
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene;
at 60 - 75 ℃;
for 1 - 2h;
|
90% |
|
chloroformic acid ethyl ester; N-methyldesloratadine;
With
N-ethyl-N,N-diisopropylamine;
In
toluene;
at 60 - 75 ℃;
for 1 - 2h;
With
hydrogenchloride;
In
water; toluene;
|
73% |
|
With
triethylamine;
In
toluene;
for 3h;
Reflux;
|
72% |
|
With
triethylamine;
In
toluene;
at 80 - 85 ℃;
for 2h;
|
71.3% |
|
In
toluene;
1.) 2 h, reflux, 2.) room temperature, overnight;
|
64% |
|
With
triethylamine;
In
toluene;
Heating;
|
|
|
In
toluene;
at 80 ℃;
for 1h;
|
42.4 g |
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene; acetonitrile;
|
42.4 g (HPLC purity 97.4%) |
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene; acetonitrile;
|
42.4 g (HPLC purity 97.4%) |
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene; acetonitrile;
|
42.4 g (HPLC purity 97.4%) |
|
With
N-ethyl-N,N-diisopropylamine;
In
toluene; acetonitrile;
|
42.4 g (HPLC purity 97.4%) |
|
chloroformic acid ethyl ester; N-methyldesloratadine;
With
triethylamine;
In
toluene;
at 70 - 75 ℃;
for 1.75h;
With
sodium hydroxide;
In
water; toluene;
for 0.333333h;
pH=9.3;
|
|
|
chloroformic acid ethyl ester; N-methyldesloratadine;
With
triethylamine;
In
toluene;
at 65 - 78 ℃;
for 2.25 - 4.25h;
With
sodium hydrogencarbonate;
In
water; toluene;
Product distribution / selectivity;
|
|
|
With
triethylamine;
In
toluene;
at 25 - 75 ℃;
for 1.5h;
|
2.What is the CAS number for Loratadine ?
The CAS number of Loratadine is 79794-75-5.
More information of Loratadine 79794-75-5 are:
|
CAS Number |
79794-75-5 |
|
Density |
1.261 g/cm3 |
|
Melting Point |
134-136 ºC |
|
Boiling Point |
531.3 ºC at 760 mmHg |
|
Flash Point |
275.1 ºC |
|
HS CODE |
DERIVATION |
|
PSA |
42.43000 |
|
LogP |
4.82570 |
|
Pka |
4.27±0.20(Predicted) |
3.What are another words for Loratadine ?
Synonyms for Loratadine 79794-75-5:Sch 29851;Bedix Loratadina;Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate;Claratyne;Biloina;Histaloran;Lorastine;Alarin;Loratadine (JAN/USAN);Loratadina [Spanish];Loradif;Claritin D;Sensibit;Loranox;1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester;Sohotin;Clarityne;Fristamin;Bonalerg;Aerotina;Claritin;Rhinase;Alerpriv;Lertamine;Allertidin;Loratadine (79794-75-5);Loratadina;Clarityne-D;Lorantis;Pylor;Lowadina;Lesidas;Loratyne;Tadine;
4.What is the molecular formula of Loratadine?
The chemical formula of Loratadine is C22H23ClN2O2 which containing 22 Carbon atoms,23 Hydrogen atoms,1 Chlorine atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Loratadine is 382.89.
5.What is Loratadine (79794-75-5) used for?
Loratadine is a non-sedating antihistamine indicated for use in allergic rhinitis and chronic urticaria. Its major advantage over other non-sedating antihistamines such as astemizole and terfenadine is its very fast onset of action. Loratadine is claimed not to cross the blood-brain barrier.
InChI:InChI=1/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
Relevant articles related to Loratadine:
|
Article |
Source |
|
Non-innocent Radical Ion Intermediates in Photoredox Catalysis: Parallel Reduction Modes Enable Coupling of Diverse Aryl Chlorides |
Chernowsky, Colleen P.,Chmiel, Alyah F.,Wickens, Zachary K.,Williams, Oliver P.,Yeung, Charles S. supporting information, p. 10882 - 10889 (2021/07/31) |
|
Loratadine and analogues: Discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B0AT2 |
Cuboni, Serena,Devigny, Christian,Hoogeland, Bastiaan,Strasser, Andrea,Pomplun, Sebastian,Hauger, Barbara,H?fner, Georg,Wanner, Klaus T.,Eder, Matthias,Buschauer, Armin,Holsboer, Florian,Hausch, Felix supporting information, p. 9473 - 9479 (2015/01/09) |
6.Buy Loratadine with the best price .
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