89-25-8
- Product Name：5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
- Molecular Formula：C10H10N2O
- Purity：99%
- Molecular Weight：174.202
Product Details;
CasNo： 89-25-8
Molecular Formula： C10H10N2O
Appearance： Off white to light yellow powder
Manufacturer supply good quality 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 89-25-8 with stock
- Molecular Formula:C10H10N2O
- Molecular Weight:174.202
- Appearance/Colour:Off white to light yellow powder
- Vapor Pressure:0.000141mmHg at 25°C
- Melting Point:126-128 °C(lit.)
- Refractive Index:1.606
- Boiling Point:333 °C at 760 mmHg
- PKA:2.73±0.50(Predicted)
- Flash Point:155.2 °C
- PSA：32.67000
- Density:1.17 g/cm3
- LogP:1.29980
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one(Cas 89-25-8) Usage
|
Definition |
ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. |
|
Brand name |
Radicut |
|
General Description |
A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore. |
|
Hazard |
Toxic by ingestion. |
|
Flammability and Explosibility |
Notclassified |
|
Biological Activity |
A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. |
|
Biochem/physiol Actions |
Product does not compete with ATP. |
|
Safety Profile |
Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx. |
|
Purification Methods |
Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.] |
InChI:InChI=1/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
89-25-8 Relevant articles
Structure and extractive ability of 1-alkyl- and 3-methyl-1-phenyl-2- pyrazolin-5-ones
Lesnov,Sazonova,Pavlov
, p. 298 - 302 (2005)
Extractive ability of 1-substituted 3-me...
Synthesis and crystal structure of 5-chloro-3-methyl-1-phenyl-1H-pyrazole- 4-carbaldehyde
Xu, Cun-Jin,Shi, Yan-Qin
, p. 1816 - 1819 (2011)
The title compound, 5-chloro-3-methyl-1-...
Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-methyl-1-substituted-1H-pyrazoles
Kang, Jing,Yue, Xia Li,Chen, Chang Shui,Li, Jian Hong,Ma, Hong Ju
, (2016)
With the objective of finding valuable h...
Click inspired novel pyrazole-triazole-persulfonimide & pyrazole-triazole-aryl derivatives; Design, synthesis, DPP-4 inhibitor with potential anti-diabetic agents
Nidhar, Manisha,Khanam, Shaziya,Sonker, Priyanka,Gupta, Priya,Mahapatra, Archisman,Patil, Swaraj,Yadav, Brijesh Kumar,Singh, Rahul Kumar,Kumar Tewari, Ashish
supporting information, (2022/01/22)
This work presented the first report on ...
Preparative, mechanistic and tautomeric investigation of 1-phenyl and 1-methyl derivative of 3-methyl-5-pyrazolone
Fakhraian, Hossein,Nafari, Yaser
, (2021/04/19)
1-Phenyl and 1-methyl derivative of 3-me...
Edaravone preparation method
-
Paragraph 0014; 0026-0045, (2021/10/27)
To the preparation method of edaravone, ...
Edaravone preparation method
-
Paragraph 0026-0042, (2021/11/26)
The edaravone preparation method compris...
89-25-8 Process route
-
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39143-08-3,25111-96-0
Z-1-phenyl-3-methyl-4-<(4-dimethylaminophenyl)methylene>-5-pyrazolone
-
-
100-10-7
4-dimethylamino-benzaldehyde
-
-
89-25-8
edaravone
| Conditions | Yield |
|---|---|
|
With
phosphate buffer; water;
In
propan-1-ol;
at 33 ℃;
Rate constant;
Mechanism;
|
-
-
59-88-1
phenylhydrazine hydrochloride
-
-
141-97-9
ethyl acetoacetate
-
-
68-12-2,33513-42-7
N,N-dimethyl-formamide
-
-
89-25-8
edaravone
-
-
61466-03-3,4174-09-8,1388851-19-1
4,4-methine-bis-(3-methyl-1-phenyl-2-pyrazolin-5-one)
| Conditions | Yield |
|---|---|
|
With
p-toluenesulfonic acid monohydrate;
at 110 ℃;
for 1h;
Reagent/catalyst;
Temperature;
Kinetics;
|
78% 12% |
|
With
pyridine hydrochloride;
at 140 ℃;
for 24h;
Reagent/catalyst;
Kinetics;
|
47% 39% |
89-25-8 Upstream products
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6078-46-2
ethyl 3-(2-phenylhydrazono)butanoate
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37959-11-8
(5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)-acetic acid
-
74169-52-1
3,4-dimethyl-1-phenyl-1H,6H-pyrano<2,3-c>pyrazol-6-one
-
64-19-7
acetic acid
89-25-8 Downstream products
-
27349-35-5
5-methoxy-3-methyl-1-phenyl-1H-pyrazole
-
115029-66-8
5,5'-dimethyl-2,2'-diphenyl-2,4-dihydro-2'H-[3,4']bipyrazolyliden-3'-one
-
32901-39-6
5-methyl-4-[(3-methyl-3H-benzoxazol-2-yliden)-ethylidene]-2-phenyl-2,4-dihydro-pyrazol-3-one
-
132603-41-9
(Z)-4-(benzo[d][1,3]dioxol-5-ylmethylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
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