21187-98-4
- Product Name：Gliclazide
- Molecular Formula：C15H21N3O3S
- Purity：99%
- Molecular Weight：323.416
Product Details;
CasNo： 21187-98-4
Molecular Formula： C15H21N3O3S
Appearance： white cyrstalline solid
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What is the Gliclazide ?
Gliclazide is white cyrstalline solid, while it's Molecular Formula is C15H21N3O3S. Gliclazide is an oral hypoglycemic agent used to treat non-insulin-dependent diabetes mellitus.Treatment of diabetes associated with obesity or vascular disease, for adults with type 2 diabetes.Diabetes is a chronic (long-lasting) health condition that affects how your body turns food into energy. Gliclazide reduces blood glucose levels by stimulating insulin secretion from the β-cells of the islets of Langerhans.
What is the CAS number for Gliclazide ?
The CAS number of Gliclazide is 21187-98-4.
More information of Gliclazide 21187-98-4 are:
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Synonyms |
Urea,1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)- (8CI);Cyclopenta[c]pyrrole, benzenesulfonamide deriv.;1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea;Diabezidum;Diabyl;Diamicron;Diaprel;Glimicron;Glinormax;Glyzide;N-(4-Methylbenzenesulfonyl)-N'-[3-azabicyclo(3,3,0)oct-3-yl]urea;S1702;S 852;SE 1702;Benzenesulfonamide,N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-; |
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CAS Number |
21187-98-4 |
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Molecular Formula |
C15H21N3O3S |
|
Molecular Weight |
323.416 |
|
Density |
1.35 g/cm3 |
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Melting Point |
163-169 °C(lit.) |
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HS CODE |
29350090 |
|
PSA |
86.89000 |
|
LogP |
3.43030 |
|
Pka |
6.07±0.10(Predicted) |
What is Gliclazide (21187-98-4) used for?
Gliclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide.
InChI:InChI=1/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
Articles related to Gliclazide:
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Article |
Source |
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Synthesis and characterization of novel oxime prodrug of G liclizide |
Vijayaraj,Anitha,Omshanthi,Sampath Kumar , p. 6989 - 6992 (2014) |
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Sulfonylurea compound synthesis method |
- Paragraph 0028; 0056-0067, (2021/11/26) |
How to get the best price on Gliclazide?
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