20859-02-3
- Product Name：L-tert-Leucine
- Molecular Formula：C6H13NO2
- Purity：99%
- Molecular Weight：131.175
Product Details;
CasNo： 20859-02-3
Molecular Formula： C6H13NO2
Appearance： white to almost white powder
Chemical plants supply high-quality L-tert-Leucine 20859-02-3 in bulk
- Molecular Formula:C6H13NO2
- Molecular Weight:131.175
- Appearance/Colour:white to almost white powder
- Vapor Pressure:0.0499mmHg at 25°C
- Melting Point:300 °C
- Refractive Index:-9 ° (C=3, H2O)
- Boiling Point:217.7 °C at 760 mmHg
- PKA:2.39±0.12(Predicted)
- Flash Point:85.5 °C
- PSA：63.32000
- Density:1.038 g/cm3
- LogP:1.14470
L-tert-Leucine(Cas 20859-02-3) Usage
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Synthesis Reference(s) |
Organic Syntheses, Coll. Vol. 3, p. 523, 1955Tetrahedron Letters, 19, p. 4625, 1978 DOI: 10.1016/S0040-4039(01)85688-4 |
InChI:InChI=1/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9)
20859-02-3 Relevant articles
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Molecular Structure of a Chiral 3,5-Bridged Pyridine and the Effect of Structure on Circular Dichroic Spectra
Speelman, Johanna C.,Talma, Auke G.,Kellogg, Richard M.,Meetsma, A.,Boer, J. L. de,et al.
, p. 1055 - 1062 (1989)
The crystal structure of the 3,5-bridged...
Design of a self-sufficient hydride-shuttling cascade for concurrent bioproduction of 7,12-dioxolithocholate andl-tert-leucine
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, p. 4125 - 4133 (2021)
Oxidoreductase-mediated biotransformatio...
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Tanabe,T. et al.
, p. 2178 - 2179 (1968)
-
SIMPLE OPTICAL RESOLUTION OF TERLEUCINE
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, p. 5865 - 5868 (1986)
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Synthesis method of L-tertiary leucine and L-cyclohexyl alanine
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Paragraph 0030-0032, (2021/08/07)
The invention discloses a synthesis meth...
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Paragraph 0036-0039, (2020/06/16)
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20859-02-3 Process route
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tert-butylmagnesium bromide-lithium chloride
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(S)-(2-methylpropane-2-sulfinimido)-acetate methyl ester
-
-
20859-02-3
L-tert-Leucine
-
-
26782-71-8
D-tert-leucine
| Conditions | Yield |
|---|---|
|
tert-butylmagnesium bromide-lithium chloride; (S)-(2-methylpropane-2-sulfinimido)-acetate methyl ester;
In
tetrahydrofuran; dichloromethane;
at -20 - 0 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride;
In
ethyl acetate;
at 30 - 35 ℃;
With
water; lithium hydroxide;
In
tetrahydrofuran;
at 25 - 30 ℃;
for 2h;
Overall yield = 84.2 percent;
|
88.2 % ee |
-
-
(R)-3,3-Dimethyl-2-(2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid
-
-
20859-02-3
L-tert-Leucine
-
-
26782-71-8
D-tert-leucine
| Conditions | Yield |
|---|---|
|
With
ammonia; lithium;
In
tetrahydrofuran; tert-butyl alcohol;
at -78 ℃;
for 0.5h;
Yield given. Title compound not separated from byproducts;
|
20859-02-3 Upstream products
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L-2-formylamino-3,3-dimethyl-butyric acid
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62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine
-
3850-31-5
methyl tert-leucinate
20859-02-3 Downstream products
-
62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine
-
63038-26-6
(S)-2-amino-3,3-dimethyl-butyric acid methyl ester
-
62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine
-
31556-73-7
Z-L-Tle-OtBu
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