745-65-3
- Product Name：Alprostadil
- Molecular Formula：C20H34O5
- Purity：99%
- Molecular Weight：354.487
Product Details;
CasNo： 745-65-3
Molecular Formula： C20H34O5
Appearance： Crystalline solid
Quality products make an important contribution to long-term revenue and profitability. Alprostadil GMP Manufacturer Global Trade 745-65-3 with Fast Delivery
1.What is the Prostaglandin E1 ?
Alprostadil (prostaglandin E1 [PGE1]; Edex, Topiglan) exerts a number of effects, including systemic vasodilation, inhibition of platelet aggregation, and stimulation of intestinal motility. PGE1 relaxes isolated smooth muscle cells contracted by norepinephrine. It has become widely used in the treatment of ED. Alprostadil binds with PGE receptors and results in a cyclic adenosine monophosphate (cAMP) mediated smooth muscle relaxation. Little is known about the pharmacokinetics of PGE1, but it is believed that as much as 80% is metabolized in one pass through the lungs. Such rapid degradation probably accounts for its lack of significant cardiovascular side effects when administered intracavernosally. PGE1 can also be metabolized in the penis.
Vasodilator;Prostaglandin receptor agonist
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3434-33-1
prostaglandin E1 methyl ester
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745-65-3
ALPROSTADIL
| Conditions | Yield |
|---|---|
|
With
porcine pancreatic lipase; sodium chloride; calcium chloride;
In
tetrahydrofuran; water;
for 0.5h;
Enzymatic reaction;
pH 7.1;
|
89% |
|
With
pig liver esterase;
In
water;
for 4h;
Ambient temperature;
|
86% |
|
With
porcine liver esterase; phosphate buffer solution;
In
acetone;
for 4h;
Ambient temperature;
|
86% |
|
With
phosphate buffer;
Baker's yeast, pH 7.0;
|
72% |
|
(microbiological transformation);
|
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1251949-12-8
C32H64O5Si2
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745-65-3
ALPROSTADIL
| Conditions | Yield |
|---|---|
|
With
hydrogen fluoride; water;
In
acetonitrile;
at 20 ℃;
for 6h;
stereoselective reaction;
|
90% |
2.What is the CAS number for Prostaglandin E1 ?
The CAS number of Prostaglandin E1 is 745-65-3.
More information of Prostaglandin E1 745-65-3 are:
|
CAS Number |
745-65-3 |
|
Density |
1.131 g/cm3 |
|
Melting Point |
115-116 °C |
|
Boiling Point |
529.3 °C at 760 mmHg |
|
Flash Point |
288 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.6120 (estimate) |
|
HS CODE |
29375000 |
|
PSA |
94.83000 |
|
LogP |
3.47510 |
|
Pka |
pKa 4.85± 0.07(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain) |
3.What are another words for Prostaglandin E1 ?
Synonyms for Prostaglandin E1 745-65-3:Cyclopentaneheptanoicacid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, (-)- (8CI);Cyclopentaneheptanoicacid, 3a-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-(7CI);(-)-Prostaglandin E1;11a,15(S)-Dihydroxy-9-oxo-13-trans-prostenoic acid;11a,15a-Dihydroxy-9-oxo-13-trans-prostenoic acid;Alprox TD;Caveject;Caverject;Eglandin;Liple;Lipoprost;Liprostin;Minprog;NSC 165559;ONO 1608;Palux;Prostandin 500;Prostin VR Pediatric;Prostivas;SEPA-PGE1;SEPA-alprostadil;Topiglan;Vasaprostan;l-PGE1;l-Prostaglandin E1;Prostaglandin E1;
4.What is the molecular formula of Prostaglandin E1?
The chemical formula of Prostaglandin E1 is C20H34O5 which containing 20 Carbon atoms,34 Hydrogen atoms and 5 Oxygen atoms,and the molecular weight of Prostaglandin E1 is 354.487.
5.What is Prostaglandin E1 (745-65-3) used for?
PGE1?(745-65-3) is an endogenous prostaglandin with vasodilatory, anti-platelet, and anti-hypertensive activities.1,2 It is in clinical use for the treatment of erectile dysfunction3 and the emergency management of infants with patent ductus arteriosus4. It has also been used in the treatment of peripheral arterial occlusive disease (PAD).5
InChI:InChI=1/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1
Relevant articles related to Prostaglandin E1:
|
Article |
Source |
|
Cautions in the synthesis of prostaglandins. C9→C 15 acetate migration |
Vostrikov,Loza,Selezneva,Miftakhov , (2014) |
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The Meyer-Schuster rearrangement: A new synthetic strategy leading to prostaglandins and their drug analogs, Bimatoprost and Latanoprost |
Zanoni, Giuseppe,D'Alfonso, Alessandro,Porta, Alessio,Feliciani, Lazzaro,Nolan, Steven P.,Vidari, Giovanni experimental part, p. 7472 - 7478 (2010/12/25) |
6.Buy Prostaglandin E1 with the best price .
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